Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis
[...]previous works have indicated that patients are able to recall symptoms of smell accurately.8 The lack of a control group makes it difficult to determine what role a placebo effect and the natural course of the disease may have played. A lack of significance in the pilot data was likely driven...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2009-12, Vol.124 (6), p.1352-1354.e7 |
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| container_end_page | 1354.e7 |
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| container_issue | 6 |
| container_start_page | 1352 |
| container_title | Journal of allergy and clinical immunology |
| container_volume | 124 |
| creator | Steinke, John W., PhD Payne, Spencer C., MD Tessier, M. Elizabeth, MD Borish, Lori O., RN Han, Joseph K., MD Borish, Larry C., MD |
| description | [...]previous works have indicated that patients are able to recall symptoms of smell accurately.8 The lack of a control group makes it difficult to determine what role a placebo effect and the natural course of the disease may have played. A lack of significance in the pilot data was likely driven by the inclusion of patients with well controlled asthma; however, 3 of 4 subjects who did not have controlled disease at baseline did show improvement.\n In addition, asthma control was determined using National Institutes of Health guidelines.E2 Each visual analogue scale (VAS) question was converted to a numerical value (0-6) to allow statistical analysis of symptoms before and after treatment (maximum sinus score for 16 symptoms, 96; maximum asthma score for 6 symptoms, 36). |
| doi_str_mv | 10.1016/j.jaci.2009.09.018 |
| format | Article |
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Elizabeth, MD</creatorcontrib><creatorcontrib>Borish, Lori O., RN</creatorcontrib><creatorcontrib>Han, Joseph K., MD</creatorcontrib><creatorcontrib>Borish, Larry C., MD</creatorcontrib><title>Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>[...]previous works have indicated that patients are able to recall symptoms of smell accurately.8 The lack of a control group makes it difficult to determine what role a placebo effect and the natural course of the disease may have played. A lack of significance in the pilot data was likely driven by the inclusion of patients with well controlled asthma; however, 3 of 4 subjects who did not have controlled disease at baseline did show improvement.\n In addition, asthma control was determined using National Institutes of Health guidelines.E2 Each visual analogue scale (VAS) question was converted to a numerical value (0-6) to allow statistical analysis of symptoms before and after treatment (maximum sinus score for 16 symptoms, 96; maximum asthma score for 6 symptoms, 36).</description><subject>Administration, Inhalation</subject><subject>Allergies</subject><subject>Allergy and Immunology</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Aspirin</subject><subject>Asthma</subject><subject>Budesonide - administration & dosage</subject><subject>Budesonide - therapeutic use</subject><subject>Chronic Disease</subject><subject>Drug therapy</subject><subject>Eosinophilia - drug therapy</subject><subject>Eosinophils - drug effects</subject><subject>Eosinophils - immunology</subject><subject>Humans</subject><subject>Medical imaging</subject><subject>Pilot Projects</subject><subject>Placebo effect</subject><subject>Respiratory diseases</subject><subject>Sinuses</subject><subject>Sinusitis - drug therapy</subject><subject>Statistical analysis</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklGL1DAQx4Mo3t7pF_BBCj741HWStmkCIhyHnsKBgvomhDSZuqndZs20wn57U3bh4B4UBjLD_GaYyX8Ye8Fhy4HLN8N2sC5sBYDersbVI7bhoNtSKtE8Zpuc4KVsa33BLokGyHGl9FN2wbXmAKLdsB9fwhjngubFH4vYF93ikeIUPBZh2tnRTjm50AEnCnEqQkrhp52zS0UfU-F2KcOuwEhhioddGHOQ3YXCHOgZe9LbkfD5-b1i3z-8_3bzsbz7fPvp5vqudLVu5rISaHknLXAt-4o7aFprbaNAIPq-swp6rKFprMemVT3IWnIlOuGdxkp7qK7Y61PfQ4q_F6TZ7AM5HPP0GBcyqpWiFgKq_5JtVXPdSMEz-eoBOcQlTXkNwxuoFZdat5kSJ8qlSJSwN4cU9jYdDQezimQGs4pkVpHMalzlopfn1ku3R39fclYlA29PAOZP-xMwGXIBJ4c-JHSz8TH8u_-7B-VuDFklO_7CI9L9HoaEAfN1PZP1SkADr0G21V-taLig</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Steinke, John W., PhD</creator><creator>Payne, Spencer C., MD</creator><creator>Tessier, M. 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Elizabeth, MD ; Borish, Lori O., RN ; Han, Joseph K., MD ; Borish, Larry C., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-32ea1b6a0196f31c057aaa5802eedfba80fe4055ade578f0646182b2dc9e39d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Inhalation</topic><topic>Allergies</topic><topic>Allergy and Immunology</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Aspirin</topic><topic>Asthma</topic><topic>Budesonide - administration & dosage</topic><topic>Budesonide - therapeutic use</topic><topic>Chronic Disease</topic><topic>Drug therapy</topic><topic>Eosinophilia - drug therapy</topic><topic>Eosinophils - drug effects</topic><topic>Eosinophils - immunology</topic><topic>Humans</topic><topic>Medical imaging</topic><topic>Pilot Projects</topic><topic>Placebo effect</topic><topic>Respiratory diseases</topic><topic>Sinuses</topic><topic>Sinusitis - drug therapy</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinke, John W., PhD</creatorcontrib><creatorcontrib>Payne, Spencer C., MD</creatorcontrib><creatorcontrib>Tessier, M. 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A lack of significance in the pilot data was likely driven by the inclusion of patients with well controlled asthma; however, 3 of 4 subjects who did not have controlled disease at baseline did show improvement.\n In addition, asthma control was determined using National Institutes of Health guidelines.E2 Each visual analogue scale (VAS) question was converted to a numerical value (0-6) to allow statistical analysis of symptoms before and after treatment (maximum sinus score for 16 symptoms, 96; maximum asthma score for 6 symptoms, 36).</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>19910027</pmid><doi>10.1016/j.jaci.2009.09.018</doi></addata></record> |
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| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2009-12, Vol.124 (6), p.1352-1354.e7 |
| issn | 0091-6749 1097-6825 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Inhalation Allergies Allergy and Immunology Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Aspirin Asthma Budesonide - administration & dosage Budesonide - therapeutic use Chronic Disease Drug therapy Eosinophilia - drug therapy Eosinophils - drug effects Eosinophils - immunology Humans Medical imaging Pilot Projects Placebo effect Respiratory diseases Sinuses Sinusitis - drug therapy Statistical analysis |
| title | Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis |
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