Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II)(2)Cys(6) transcriptional activator and induced by kojic acid at the transcriptional level

A gene encoding the Zn(II)(2)Cys(6) transcriptional factor is clustered with two genes involved in biosynthesis of a secondary metabolite, kojic acid (KA), in Aspergillus oryzae. We determined that the gene was essential for KA production and the transcriptional activation of KA biosynthetic genes,...

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Veröffentlicht in:	Journal of bioscience and bioengineering 2011-07, Vol.112 (1), p.40-43
Hauptverfasser:	Marui, Junichiro, Yamane, Noriko, Ohashi-Kunihiro, Sumiko, Ando, Tomohiro, Terabayashi, Yasunobu, Sano, Motoaki, Ohashi, Shinichi, Ohshima, Eiji, Tachibana, Kuniharu, Higa, Yoshitaka, Nishimura, Marie, Koike, Hideaki, Machida, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus oryzae - genetics Aspergillus oryzae - metabolism Cysteine - biosynthesis Cysteine - genetics Cysteine - metabolism DNA, Fungal - metabolism Fungal Proteins - biosynthesis Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation, Fungal - drug effects Genes, Fungal Pyrones - metabolism Trans-Activators - metabolism Transcription Factors - biosynthesis Transcriptional Activation - drug effects
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Zusammenfassung:	A gene encoding the Zn(II)(2)Cys(6) transcriptional factor is clustered with two genes involved in biosynthesis of a secondary metabolite, kojic acid (KA), in Aspergillus oryzae. We determined that the gene was essential for KA production and the transcriptional activation of KA biosynthetic genes, which were triggered by the addition of KA.
ISSN:	1347-4421
DOI:	10.1016/j.jbiosc.2011.03.010