Lycorine induces cell death in the amitochondriate parasite, Trichomonas vaginalis, via an alternative non-apoptotic death pathway

Lycorine is cytotoxic against the amitochondriate parasite Trichomonas vaginalis by a mechanism of action that fails to fulfill the apoptotic-like cell death already described. [Display omitted] ► The alkaloid lycorine was cytotoxic against the amitochondriate Trichomonas vaginalis. ► Important ultr...

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Veröffentlicht in:	Phytochemistry (Oxford) 2011-05, Vol.72 (7), p.645-650
Hauptverfasser:	Giordani, Raquel Brandt, Vieira, Patrícia de Brum, Weizenmann, Marina, Rosemberg, Denis Broock, Souza, Ana Paula, Bonorino, Cristina, De Carli, Geraldo Attilio, Bogo, Maurício Reis, Zuanazzi, José Angelo, Tasca, Tiana
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Amaryllidaceae Amaryllidaceae Alkaloids - pharmacology Amitochondriate Biological and medical sciences cell cycle Cell Cycle - drug effects cell death Cell Death - drug effects Cell death pathway Chemical constitution cytotoxicity death Dose-Response Relationship, Drug electron microscopy Fundamental and applied biological sciences. Psychology Hippeastrum santacatarina Lycorine mechanism of action Microscopy, Electron, Transmission Parasite parasites Phenanthridines - pharmacology Plant physiology and development Trichomonas vaginalis Trichomonas vaginalis - cytology Trichomonas vaginalis - drug effects Trichomonas vaginalis - ultrastructure
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