Lycorine induces cell death in the amitochondriate parasite, Trichomonas vaginalis, via an alternative non-apoptotic death pathway

Lycorine is cytotoxic against the amitochondriate parasite Trichomonas vaginalis by a mechanism of action that fails to fulfill the apoptotic-like cell death already described. [Display omitted] ► The alkaloid lycorine was cytotoxic against the amitochondriate Trichomonas vaginalis. ► Important ultr...

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Veröffentlicht in:Phytochemistry (Oxford) 2011-05, Vol.72 (7), p.645-650
Hauptverfasser: Giordani, Raquel Brandt, Vieira, Patrícia de Brum, Weizenmann, Marina, Rosemberg, Denis Broock, Souza, Ana Paula, Bonorino, Cristina, De Carli, Geraldo Attilio, Bogo, Maurício Reis, Zuanazzi, José Angelo, Tasca, Tiana
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Sprache:eng
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Zusammenfassung:Lycorine is cytotoxic against the amitochondriate parasite Trichomonas vaginalis by a mechanism of action that fails to fulfill the apoptotic-like cell death already described. [Display omitted] ► The alkaloid lycorine was cytotoxic against the amitochondriate Trichomonas vaginalis. ► Important ultrastructural alterations were observed by electron microscopy. ► Lycorine arrested the T. vaginalis cell cycle. ► Similarities to paraptotic cell death were found. ► Our results contribute to the lycorine mechanisms of action on eukaryotic cells. In this study, the mechanism of action of the pro-apoptotic alkaloid lycorine on an amitochondriate cell, the parasite Trichomonas vaginalis, was investigated. The cytotoxicity of lycorine against T. vaginalis was studied from 2.5 to 1000 μM and several important ultrastructural alterations were observed by electron microscopy. Lycorine arrested the T. vaginalis cell cycle, although no hallmarks of apoptosis, such as apoptotic bodies, were observed. Consequently, the underlying mechanism of action fails to completely fulfill the criteria for apoptosis. However, some similarities to paraptotic cell death were observed.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2011.01.023