PET evaluation of the TSPO ligands [F-18]FEPPA, [F-18]PRB06, and [F-18]PBR111 in nonhuman primate

PET evaluation of the TSPO ligands [F-18]FEPPA, [F-18]PRB06, and [F-18]PBR111 in nonhuman primate

Modeling analysis of displacement data was not reliable, since PK11195 produced dramatic changes in the tracer input function, which were inadequately characterized by the relatively sparse blood samples acquired. Conclusions: Based on these analyses, our data suggest that both [18F]PBR06 and [18F]P...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2010-08, Vol.52 (S1), p.S147-S147
Hauptverfasser: Carson, Richard E., Weinzimmer, David P., Koren, Andrei, Alagille, David, Fowles, Krista, Ashworth, Sharon, Seibyl, John P., Katsifis, Andrew, Gunn, Roger N., Rabiner, Eugenii A., Tang, Sac-Pham, Tamagnan, Gilles
Format: Artikel
Sprache:eng
Schlagworte:
Ligands
Metabolites
Studies
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Zusammenfassung:Modeling analysis of displacement data was not reliable, since PK11195 produced dramatic changes in the tracer input function, which were inadequately characterized by the relatively sparse blood samples acquired. Conclusions: Based on these analyses, our data suggest that both [18F]PBR06 and [18F]PBR111 have suitable kinetic profiles for TSPO PET studies, with [18F]PBR06 having more favorable properties.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.04.121