Automated GMP production of [11C]PR04.MZ via the captive solvent method and PET studies in non-human primates: A promising tracer for extrastriatal DAT imaging

Automated GMP production of [11C]PR04.MZ via the captive solvent method and PET studies in non-human primates: A promising tracer for extrastriatal DAT imaging

Time-activity curves and distribution volumes (DVs) were derived for the putamen, the caudate nucleus, the nucleus accumbens, the midbrain and the cerebellum. Distribution volumes (DV) for various brain regions were obtained from Logan-plot analysis and binding potentials were calculated according t...

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Veröffentlicht in:NeuroImage 2010-08, Vol.52 (S1), p.S117-S117
Hauptverfasser: Riss, Patrick J., Hooker, Jacob M., Alexoff, David, Kim, Sung-Won, Hummerich, Rene, Ferrari, Valentina A., Schloss, Patrick, Fowler, Johanna S., Roesch, Frank, Aigbirhio, Franklin I.
Format: Artikel
Sprache:eng
Schlagworte:
[11C]PRO.4.MZ
Automation
BRAIN
Dopamine
human primates
PET
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
PRODUCTION
RADIOLOGY AND NUCLEAR MEDICINE
radiotracer
Rodents
SOLVENTS
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Zusammenfassung:Time-activity curves and distribution volumes (DVs) were derived for the putamen, the caudate nucleus, the nucleus accumbens, the midbrain and the cerebellum. Distribution volumes (DV) for various brain regions were obtained from Logan-plot analysis and binding potentials were calculated according to the two compartment simplified-reference-tissue-model (SRTM).
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.04.096