The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

The transcription factor BATF is known to control switched antibody responses. Murphy and colleagues show that BATF functions at multiple hierarchical levels in follicular helper T cells and B cells to regulate these responses. The transcription factor BATF controls the differentiation of interleukin 17 (IL-17)-producing helper T cells (T H 17 cells) by regulating expression of the transcription factor RORγt itself and RORγt target genes such as Il17 . Here we report the mechanism by which BATF controls in vivo class-switch recombination (CSR). In T cells, BATF directly controlled expression of the transcription factors Bcl-6 and c-Maf, both of which are needed for development of follicular helper T cells (T FH cells). Restoring T FH cell activity to Batf −/− T cells in vivo required coexpression of Bcl-6 and c-Maf. In B cells, BATF directly controlled the expression of both activation-induced cytidine deaminase (AID) and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I H -C H ). Thus, BATF functions at multiple hierarchical levels in two cell types to globally regulate switched antibody responses in vivo .