Improvement of Cytokine Response and Survival Time by Bioartificial Kidney Therapy in Acute Uremic Pigs with Multi-Organ Dysfunction

Objective To explore whether bioartificial kidney (BAK) ameliorates cytokine response and biochemical indices, and prolongs the survival time in acute uremic pigs with multiple organ dysfunction syndrome (MODS). Methods Hybridized pigs suffering from MODS and acute renal failure (ARF) were treated with BAK (Group A, n=6) or sham-BAK containing no cells (Group B, n=6), or received no treatment (Group C, n=5). Data on blood pressure, hepatic and renal function, IL-10, TNF-α, arterial blood gas, and survival time of all the pigs was recorded. Results Mean arterial pressure (MAP, mmHg) responded more rapidly and reached higher values in Group A (91.82±5.73) compared with Groups B and C at 24 hours (p