Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury

To elucidate the molecular mechanism involved in methylmercury-induced cerebellar disorder, we performed DNA microarray analysis of the cerebellum of methylmercury-treated mice. The expression levels of 21 genes were elevated 2-fold or higher in response to methylmercury, including many genes encodi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of toxicological sciences 2011/06/01, Vol.36(3), pp.389-391
Hauptverfasser:	Hwang, Gi-Wook, Lee, Jin-Yong, Ryoke, Katsunori, Matsuyama, Fujio, Kim, Jong-Mu, Takahashi, Tsutomu, Naganuma, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cerebellum Cerebellum - drug effects Cerebellum - pathology Chemokines Environmental Pollutants - toxicity Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Male Methylmercury Methylmercury Compounds - toxicity Mice Mice, Inbred C57BL Oligonucleotide Array Sequence Analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To elucidate the molecular mechanism involved in methylmercury-induced cerebellar disorder, we performed DNA microarray analysis of the cerebellum of methylmercury-treated mice. The expression levels of 21 genes were elevated 2-fold or higher in response to methylmercury, including many genes encoding proteins involved in inflammatory reactions associated with chemokines. The expression levels of 11 genes were reduced by half or more in response to methylmercury.
ISSN:	0388-1350 1880-3989 1880-3989
DOI:	10.2131/jts.36.389