Morphofunctional Characteristics of Fetoplacental Barrier of Placental Villi during Pregnancy Complicated by Herpes-Virus Infection

Analysis of placenta homogenate from pregnant women having an episode of herpes-virus infection during the third trimester revealed suppression of Bcl-2 protein activity and increase in caspase 3 concentration. Activity of Bcl-2 protein decreases with increasing the titer of antibodies to herpes vir...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2010-10, Vol.149 (4), p.537-539
Hauptverfasser:	Lutsenko, M. T, Andrievskaya, I. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bcl-2 protein Biomedical and Life Sciences Biomedicine Caspase 3 - metabolism caspase-3 Cell Biology Chorionic Villi - metabolism Chorionic Villi - pathology Female Health aspects Herpes Herpes Simplex - metabolism Herpes Simplex - pathology Herpesvirus Herpesvirus 1, Human Herpesvirus diseases Humans Internal Medicine Laboratory Medicine Pathology Physiological aspects Placenta - metabolism Pregnancy Pregnancy Complications, Infectious - metabolism Pregnancy Complications, Infectious - pathology Pregnancy Trimester, Third Pregnant women Proto-Oncogene Proteins c-bcl-2 - metabolism syncytiotrophoblast Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Trophoblasts - metabolism
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Zusammenfassung:	Analysis of placenta homogenate from pregnant women having an episode of herpes-virus infection during the third trimester revealed suppression of Bcl-2 protein activity and increase in caspase 3 concentration. Activity of Bcl-2 protein decreases with increasing the titer of antibodies to herpes virus. Increased caspase-3 activity increases the risk of DNA damage in syncytiotrophoblast nuclei.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-0987-z