Genotoxicity of platinum in embryos of zebrafish ( Danio rerio) and ramshorn snail ( Marisa cornuarietis)
The metal platinum is inter alia used for industrial and medical purposes. Due to its application in automobile catalytic converters and as an anti-cancer drug, Pt enters the aquatic environment via road runoff and hospital sewage and raises concerns about its environmental impact and toxicity to or...
Gespeichert in:
Veröffentlicht in: | The Science of the total environment 2011-05, Vol.409 (11), p.2114-2119 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The metal platinum is
inter alia used for industrial and medical purposes. Due to its application in automobile catalytic converters and as an anti-cancer drug, Pt enters the aquatic environment
via road runoff and hospital sewage and raises concerns about its environmental impact and toxicity to organisms. Therefore, the genotoxicity of Pt at 0, 0.1, 1, 10, 50, 100 and 200
μg/l PtCl
2 was tested on two freshwater organisms, zebrafish (
Danio rerio) and ramshorn snail (
Marisa cornuarietis) using the single cell gel electrophoresis, also called comet assay. PtCl
2 did not show any genotoxicity for
D. rerio at the tested concentrations, whereas significantly elevated DNA damage was observed in
M. cornuarietis at 1
μg/l PtCl
2 and beyond. The results of the study suggest a high sensitivity of
M. cornuarietis concerning the genotoxic impact of PtCl
2.
► We tested the genotoxicity of the heavy metal platinum using the comet assay. ► Model organisms were the freshwater species Danio rerio and Marisa cornuarietis. ► Genotoxicity of the tested concentrations was only found for M. cornuarietis. |
---|---|
ISSN: | 0048-9697 1879-1026 |
DOI: | 10.1016/j.scitotenv.2011.01.060 |