Papular-purpuric gloves and socks syndrome

Sporadic association with other viruses - varicella zoster, Epstein-Barr, cytomegalovirus, herpesvirus 6/7, Cocksackie, hepatitis B, and rubella - has been reported.23 Parvovirus infections are transmitted by respiratory droplets, and infectivity ceases with the appearance of skin lesions.4 Adverse drug reactions similar to papular-purpuric gloves and socks syndrome have been reported with co-trimoxazole use.5 Some patients have systemic symptoms, including fever, lymphadenopathy, asthenia, myalgia, and arthralgia. Parvovirus-B19 infection is also associated with miscarriages and hydrops fetalis.4 The pathogenesis is most likely due to immune complex deposition, a theory that is further supported by the detection of IgM immune complexes during the acute disease in our patient.3,4 Treatment includes bed rest, NSAIDs and topical steroids.