Fetal therapy of severe symptomatic toxoplasmosis using azithromycin

Severe symptomatic fetal toxoplasmosis rarely occurs after the maternal primary infection of Toxoplasma gondii. We herein report our experience of fetal therapy of symptomatic toxoplasmosis using azithromycin. Ultrasound assessment at 23 weeks' gestation revealed fetal ascites, cardiac effusion...

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Veröffentlicht in:	The journal of obstetrics and gynaecology research 2011-07, Vol.37 (7), p.953-957
Hauptverfasser:	Tamaru, Shunsuke, Kikuchi, Akihiko, Takagi, Kimiyo, Wakamatsu, Masao, Horikoshi, Tsuguhiro, Ogiso, Yoshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiprotozoal Agents - therapeutic use Ascites Azithromycin Azithromycin - therapeutic use Birth Calcification (ectopic) Chorioretinitis Drug Therapy, Combination Drugs Effusion Female Fetal Diseases - diagnostic imaging Fetal Diseases - drug therapy fetal therapy fetal toxoplasmosis Fetuses Gestation Heart Humans Hydrocephalus Immunoglobulin G Immunoglobulin M Infants Infection Live Birth Meningitis Obstetrics Oral administration Placenta prenatal diagnosis Pyrimethamine serological screening Severity of Illness Index Side effects Sulfadiazine Sulfadoxine Toxoplasma gondii Toxoplasmosis Toxoplasmosis, Congenital - drug therapy Treatment Outcome Ultrasonography, Prenatal Ultrasound Vagina Ventricle (lateral) Young Adult
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Zusammenfassung:	Severe symptomatic fetal toxoplasmosis rarely occurs after the maternal primary infection of Toxoplasma gondii. We herein report our experience of fetal therapy of symptomatic toxoplasmosis using azithromycin. Ultrasound assessment at 23 weeks' gestation revealed fetal ascites, cardiac effusion, cardiomegaly, enlarged lateral ventricles and thickened placenta. Serum Toxoplasma gondii antibody titer was ×81 920. Toxoplasma immunoglobulin M was 2.4 index (normal,
ISSN:	1341-8076 1447-0756
DOI:	10.1111/j.1447-0756.2010.01459.x