Endoglin (CD105): A Review of its Role in Angiogenesis and Tumor Diagnosis, Progression and Therapy
Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrat...
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| Veröffentlicht in: | Anticancer research 2011-06, Vol.31 (6), p.2283-2290 |
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| creator | NASSIRI, Farshad CUSIMANO, Michael D SCHEITHAUER, Bernd W ROTONDO, Fabio FAZIO, Alessandra YOUSEF, George M SYRO, Luis V KOVACS, Kalman LLOYD, Ricardo V |
| description | Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrate the potential of endoglin in tumor diagnosis, prognosis, and therapy. This review details the structure and function of endoglin, and investigates the role of endoglin in angiogenesis and tumor diagnosis, prognosis, and therapy. |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antigens, CD - metabolism Biological and medical sciences Endoglin Humans Medical sciences Neoplasms - blood supply Neoplasms - metabolism Neovascularization, Pathologic - metabolism Receptors, Cell Surface - metabolism Tumors |
| title | Endoglin (CD105): A Review of its Role in Angiogenesis and Tumor Diagnosis, Progression and Therapy |
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