Endoglin (CD105): A Review of its Role in Angiogenesis and Tumor Diagnosis, Progression and Therapy

Endoglin (CD105): A Review of its Role in Angiogenesis and Tumor Diagnosis, Progression and Therapy

Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrat...

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Veröffentlicht in:Anticancer research 2011-06, Vol.31 (6), p.2283-2290
Hauptverfasser: NASSIRI, Farshad, CUSIMANO, Michael D, SCHEITHAUER, Bernd W, ROTONDO, Fabio, FAZIO, Alessandra, YOUSEF, George M, SYRO, Luis V, KOVACS, Kalman, LLOYD, Ricardo V
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antigens, CD - metabolism
Biological and medical sciences
Endoglin
Humans
Medical sciences
Neoplasms - blood supply
Neoplasms - metabolism
Neovascularization, Pathologic - metabolism
Receptors, Cell Surface - metabolism
Tumors
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Zusammenfassung:Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrate the potential of endoglin in tumor diagnosis, prognosis, and therapy. This review details the structure and function of endoglin, and investigates the role of endoglin in angiogenesis and tumor diagnosis, prognosis, and therapy.
ISSN:0250-7005
1791-7530