Development of chronic hepatitis B virus infection in hepatitis B surface antigen negative HIV/HBV co-infected adults: A rare opportunistic illness

Changes in serologic status in human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co‐infected individuals with either isolated anti‐HBc or resolved HBV infection have been reported, but the frequency of clinically meaningful long‐term serologic changes is not well‐defined. This study therefo...

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Veröffentlicht in:Journal of medical virology 2011-09, Vol.83 (9), p.1537-1543
Hauptverfasser: Landrum, Michael L., Roediger, Mollie P., Fieberg, Ann M., Weintrob, Amy C., Okulicz, Jason F., Crum-Cianflone, Nancy F., Ganesan, Anuradha, Lalani, Tahaniyat, Macalino, Grace E., Chun, Helen M.
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Sprache:eng
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Zusammenfassung:Changes in serologic status in human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co‐infected individuals with either isolated anti‐HBc or resolved HBV infection have been reported, but the frequency of clinically meaningful long‐term serologic changes is not well‐defined. This study therefore, examined longitudinal serologic status for hepatitis B surface antigen (HBsAg)‐negative HIV/HBV co‐infected participants in a large cohort. Among 5,222 cohort participants, 347 (7%) were initially isolated anti‐HBc positive, and 1,073 (21%) had resolved HBV infection (concurrently reactive for anti‐HBc and anti‐HBs). Thirty‐three (10%) of the 347 participants with isolated anti‐HBc were later positive for HBsAg at least once, compared with 3 (0.3%) of those with resolved HBV (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.22155