Carbamazepine and Valproate as Adjuncts in the Treatment of Alcohol Withdrawal Syndrome: A Retrospective Cohort Study

To compare the clinical course, incidence of withdrawal seizures (WS) or delirium tremens (DT) and side effects during treatment of alcohol withdrawal in patients treated with either carbamazepine (CBZ) or valproate (VPA) as an adjunct to clomethiazole and clonidine therapy. Retrospective analysis o...

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Veröffentlicht in:	Alcohol and alcoholism (Oxford) 2011-03, Vol.46 (2), p.177-184
Hauptverfasser:	EYER, Florian, SCHRECKENBERG, Meike, HECHT, Daniela, ADORJAN, Krisztina, SCHUSTER, Tibor, FELGENHAUER, Norbert, PFAB, Rudi, STRUBEL, Tim, ZILKER, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcohol Withdrawal Delirium - complications Alcohol Withdrawal Delirium - drug therapy Alcohol Withdrawal Delirium - prevention & control Alcohol Withdrawal Seizures - complications Alcohol Withdrawal Seizures - drug therapy Alcohol Withdrawal Seizures - prevention & control Alcoholism and acute alcohol poisoning Anticonvulsants - adverse effects Anticonvulsants - blood Anticonvulsants - therapeutic use Biological and medical sciences Carbamazepine Carbamazepine - adverse effects Carbamazepine - blood Carbamazepine - therapeutic use Central nervous system Cohort Studies Ethanol - adverse effects Female Humans Intensive care Male Medical sciences Middle Aged Retrospective Studies Seizures Side effects Substance Withdrawal Syndrome - drug therapy Time Factors Toxicology Treatment methods Treatment Outcome Valproic Acid - adverse effects Valproic Acid - blood Valproic Acid - therapeutic use
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Zusammenfassung:	To compare the clinical course, incidence of withdrawal seizures (WS) or delirium tremens (DT) and side effects during treatment of alcohol withdrawal in patients treated with either carbamazepine (CBZ) or valproate (VPA) as an adjunct to clomethiazole and clonidine therapy. Retrospective analysis of charts of two cohorts of inpatients treated during 2000-2009: CBZ 374 patients, VPA 453 patients. At baseline, those treated with VPA and those treated with CBZ were similar except for a trend to younger age and a higher incidence of previous WS in the CBZ group. The median duration of pharmacological treatment (91 vs. 76 h; P
ISSN:	0735-0414 1464-3502
DOI:	10.1093/alcalc/agr005