Cardiolipin Synthase-1 mRNA Expression Does Not Correlate with Endogenous Cardiolipin Synthase Enzyme Activity In Vitro and In Vivo in Mammalian Lipopolysaccharide Models of Inflammation

We examined if lipopolysaccharide (LPS) treatment of mice affected cardiolipin (CL) synthesis. Mice were injected i.p. with LPS, the liver harvested, and CL synthase (CLS) enzyme activity and its mRNA expression examined. Treatment of mice with LPS resulted in a 55% decrease ( p

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Inflammation 2011-08, Vol.34 (4), p.247-254
Hauptverfasser:	Lu, Biao, Xu, Fred Y., Taylor, William A., Feingold, Kenneth R., Hatch, Grant M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Biomedical and Life Sciences Biomedicine Cardiolipins - biosynthesis Cardiolipins - metabolism Cell Line Hep G2 Cells Humans Immunology Internal Medicine Lipopolysaccharides - immunology Liver - drug effects Liver - metabolism Macrophages - drug effects Macrophages - metabolism Membrane Proteins - biosynthesis Membrane Proteins - genetics Mice Mice, Inbred C57BL Mitochondria - metabolism Pathology Pharmacology/Toxicology Phospholipids - analysis Rheumatology RNA, Messenger - biosynthesis Transferases (Other Substituted Phosphate Groups) - biosynthesis Transferases (Other Substituted Phosphate Groups) - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We examined if lipopolysaccharide (LPS) treatment of mice affected cardiolipin (CL) synthesis. Mice were injected i.p. with LPS, the liver harvested, and CL synthase (CLS) enzyme activity and its mRNA expression examined. Treatment of mice with LPS resulted in a 55% decrease ( p
ISSN:	0360-3997 1573-2576
DOI:	10.1007/s10753-010-9230-3