New water-soluble Mn-porphyrin with catalytic activity for superoxide dismutation and peroxynitrite decomposition
We have synthesized a new water-soluble cationic Mn-porphyrin with catalytic activity for both superoxide dismutation and peroxynitrite decomposition. The resulting Mn-porphyrin also showed higher stability for reactive oxygen species such as hydrogen peroxide and lower cytotoxicity, when compared w...
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| Veröffentlicht in: | Metallomics 2011-07, Vol.3 (7), p.744-748 |
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| container_title | Metallomics |
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| creator | Asayama, Shoichiro Nakajima, Takumi Kawakami, Hiroyoshi |
| description | We have synthesized a new water-soluble cationic Mn-porphyrin with catalytic activity for both superoxide dismutation and peroxynitrite decomposition. The resulting Mn-porphyrin also showed higher stability for reactive oxygen species such as hydrogen peroxide and lower cytotoxicity, when compared with a control normal Mn-porphyrin. Furthermore, the new porphyrin recovered the viability of lipopolysaccharide-stimulated macrophage RAW 264.7 cells but the control Mn-porphyrin did not. |
| doi_str_mv | 10.1039/c1mt00005e |
| format | Article |
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The resulting Mn-porphyrin also showed higher stability for reactive oxygen species such as hydrogen peroxide and lower cytotoxicity, when compared with a control normal Mn-porphyrin. 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| ispartof | Metallomics, 2011-07, Vol.3 (7), p.744-748 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Antioxidants - pharmacology Ascorbic Acid - pharmacology Catalysis - drug effects Cell Survival - drug effects Hydrogen Peroxide - chemistry Lipopolysaccharides - pharmacology Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Manganese - chemistry Metalloporphyrins - chemistry Mice Peroxynitrous Acid - chemistry Solubility - drug effects Superoxides - chemistry Time Factors Water - chemistry |
| title | New water-soluble Mn-porphyrin with catalytic activity for superoxide dismutation and peroxynitrite decomposition |
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