New water-soluble Mn-porphyrin with catalytic activity for superoxide dismutation and peroxynitrite decomposition

We have synthesized a new water-soluble cationic Mn-porphyrin with catalytic activity for both superoxide dismutation and peroxynitrite decomposition. The resulting Mn-porphyrin also showed higher stability for reactive oxygen species such as hydrogen peroxide and lower cytotoxicity, when compared w...

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Veröffentlicht in:	Metallomics 2011-07, Vol.3 (7), p.744-748
Hauptverfasser:	Asayama, Shoichiro, Nakajima, Takumi, Kawakami, Hiroyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Ascorbic Acid - pharmacology Catalysis - drug effects Cell Survival - drug effects Hydrogen Peroxide - chemistry Lipopolysaccharides - pharmacology Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Manganese - chemistry Metalloporphyrins - chemistry Mice Peroxynitrous Acid - chemistry Solubility - drug effects Superoxides - chemistry Time Factors Water - chemistry
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Zusammenfassung:	We have synthesized a new water-soluble cationic Mn-porphyrin with catalytic activity for both superoxide dismutation and peroxynitrite decomposition. The resulting Mn-porphyrin also showed higher stability for reactive oxygen species such as hydrogen peroxide and lower cytotoxicity, when compared with a control normal Mn-porphyrin. Furthermore, the new porphyrin recovered the viability of lipopolysaccharide-stimulated macrophage RAW 264.7 cells but the control Mn-porphyrin did not.
ISSN:	1756-5901 1756-591X
DOI:	10.1039/c1mt00005e