Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding
Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously “unfoldable” miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfi...
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Veröffentlicht in: | Angewandte Chemie International Edition 2011-07, Vol.50 (29), p.6527-6529 |
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creator | de Araujo, Aline Dantas Callaghan, Brid Nevin, Simon T. Daly, Norelle L. Craik, David J. Moretta, Melissa Hopping, Gene Christie, Macdonald J. Adams, David J. Alewood, Paul F. |
description | Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously “unfoldable” miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds. |
doi_str_mv | 10.1002/anie.201101642 |
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KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4762-dcb842d36de71885366071a3821d758149abc2768e4ce9333a23340ee6372b533</citedby><cites>FETCH-LOGICAL-c4762-dcb842d36de71885366071a3821d758149abc2768e4ce9333a23340ee6372b533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201101642$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201101642$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21630402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Araujo, Aline Dantas</creatorcontrib><creatorcontrib>Callaghan, Brid</creatorcontrib><creatorcontrib>Nevin, Simon T.</creatorcontrib><creatorcontrib>Daly, Norelle L.</creatorcontrib><creatorcontrib>Craik, David J.</creatorcontrib><creatorcontrib>Moretta, Melissa</creatorcontrib><creatorcontrib>Hopping, Gene</creatorcontrib><creatorcontrib>Christie, Macdonald J.</creatorcontrib><creatorcontrib>Adams, David J.</creatorcontrib><creatorcontrib>Alewood, Paul F.</creatorcontrib><title>Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. 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Callaghan, Brid ; Nevin, Simon T. ; Daly, Norelle L. ; Craik, David J. ; Moretta, Melissa ; Hopping, Gene ; Christie, Macdonald J. ; Adams, David J. ; Alewood, Paul F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4762-dcb842d36de71885366071a3821d758149abc2768e4ce9333a23340ee6372b533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Amino Acid Sequence</topic><topic>Analgesics - chemical synthesis</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Conotoxins - chemical synthesis</topic><topic>Conotoxins - pharmacology</topic><topic>disulfides</topic><topic>Ganglia, Spinal - cytology</topic><topic>Ganglia, Spinal - drug effects</topic><topic>Inhibitory Concentration 50</topic><topic>ion channels</topic><topic>Molecular Sequence Data</topic><topic>Neurons - drug effects</topic><topic>peptides</topic><topic>Protein Folding</topic><topic>regioselective folding</topic><topic>selenocysteine</topic><topic>Selenocysteine - chemistry</topic><topic>Xenopus laevis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Araujo, Aline Dantas</creatorcontrib><creatorcontrib>Callaghan, Brid</creatorcontrib><creatorcontrib>Nevin, Simon T.</creatorcontrib><creatorcontrib>Daly, Norelle L.</creatorcontrib><creatorcontrib>Craik, David J.</creatorcontrib><creatorcontrib>Moretta, Melissa</creatorcontrib><creatorcontrib>Hopping, Gene</creatorcontrib><creatorcontrib>Christie, Macdonald J.</creatorcontrib><creatorcontrib>Adams, David J.</creatorcontrib><creatorcontrib>Alewood, Paul F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Araujo, Aline Dantas</au><au>Callaghan, Brid</au><au>Nevin, Simon T.</au><au>Daly, Norelle L.</au><au>Craik, David J.</au><au>Moretta, Melissa</au><au>Hopping, Gene</au><au>Christie, Macdonald J.</au><au>Adams, David J.</au><au>Alewood, Paul F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. 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subjects | Amino Acid Sequence Analgesics - chemical synthesis Analgesics - pharmacology Animals Conotoxins - chemical synthesis Conotoxins - pharmacology disulfides Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Inhibitory Concentration 50 ion channels Molecular Sequence Data Neurons - drug effects peptides Protein Folding regioselective folding selenocysteine Selenocysteine - chemistry Xenopus laevis |
title | Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding |
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