Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding

Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding

Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously “unfoldable” miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfi...

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Veröffentlicht in:Angewandte Chemie International Edition 2011-07, Vol.50 (29), p.6527-6529
Hauptverfasser: de Araujo, Aline Dantas, Callaghan, Brid, Nevin, Simon T., Daly, Norelle L., Craik, David J., Moretta, Melissa, Hopping, Gene, Christie, Macdonald J., Adams, David J., Alewood, Paul F.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Analgesics - chemical synthesis
Analgesics - pharmacology
Animals
Conotoxins - chemical synthesis
Conotoxins - pharmacology
disulfides
Ganglia, Spinal - cytology
Ganglia, Spinal - drug effects
Inhibitory Concentration 50
ion channels
Molecular Sequence Data
Neurons - drug effects
peptides
Protein Folding
regioselective folding
selenocysteine
Selenocysteine - chemistry
Xenopus laevis
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Zusammenfassung:Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously “unfoldable” miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201101642