Lymphoid depletion in two dogs with nodularin intoxication

The third dog showed hepatic and renal necrosis, indicative of nodularin intoxication, but no signs of lymphoid depletion at postmortem examination or histological examination. Since the focus of the present study was to demonstrate the occurrence of lymphoid changes as a potentially new or unrecognised aspect of nodularin intoxication in carnivores, no further description of the clinical and pathological findings in the third dog is included in this report. The simultaneous onset of clinical signs associated with characteristic hepatic and renal lesions in these dogs, following ingestion of water containing a nodularin-producing algal bloom, are indicative of nodularin intoxication. [...]although cyanobacteria are primarily known as potent nephrotoxins and hepatotoxins, intoxication must also be taken into consideration as a differential diagnosis of lymphoid depletion.