Determinants of Corneal Biomechanical Properties in an Adult Chinese Population

Purpose To investigate variations in corneal hysteresis (CH) and corneal resistance factor (CRF) and their ocular and systemic associations in Chinese adults. Design Population-based, cross-sectional study. Participants We included 1136 subjects of Chinese origin from an ongoing population-based study. Methods All subjects in this population-based study underwent a standardized ocular examination including keratometry (corneal radius of curvature), intraocular pressure (IOP) measurement with Goldmann applanation tonometry, central corneal thickness (CCT), and axial length (AL) assessments. The CH and CRF were measured with the Ocular Response Analyzer. Participants underwent a detailed interview and laboratory investigations that included estimation of nonfasting serum glucose, glycosylated hemoglobin, and lipid profile. Main Outcome Measures We assessed CH, CRF, and their associations with demographic, ocular, and systemic factors. Results The mean age of study subjects was 55.3±8.4 years and 51.2% were females. The mean CH and CRF were 10.6±1.5 and 10.1±1.6 mmHg, respectively. Women had higher mean CH (10.8 vs 10.4 mmHg; P