Roles of Multidrug Efflux Pumps on the Biofilm Formation of Escherichia coli K-12

We genetically analyzed the roles of multidrug efflux pumps on the biofilm formation of Escherichia coli K-12 BW25113. We used 22 mutants missing various genes related to the multidrug efflux pumps and found that the biofilm formation of emrD, emrE, emrK, acrD, acre and mdtE-deleted mutants was extr...

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Veröffentlicht in:	Biocontrol Science 2011, Vol.16(2), pp.69-72
Hauptverfasser:	MATSUMURA, KAYO, FURUKAWA, SOICHI, OGIHARA, HIROKAZU, MORINAGA, YASUSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Biofilm Biofilms Biofilms - growth & development Biological control Drug Resistance, Multiple, Bacterial Escherichia coli Escherichia coli K12 - genetics Escherichia coli K12 - growth & development Gene Deletion Genes, Bacterial - genetics Genes, Bacterial - physiology Genes, MDR - physiology Hydrophobic and Hydrophilic Interactions Multidrug efflux pump Polystyrenes - chemistry Surface Properties
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Zusammenfassung:	We genetically analyzed the roles of multidrug efflux pumps on the biofilm formation of Escherichia coli K-12 BW25113. We used 22 mutants missing various genes related to the multidrug efflux pumps and found that the biofilm formation of emrD, emrE, emrK, acrD, acre and mdtE-deleted mutants was extremely decreased. These results indicate that some multidrug efflux pumps significantly contribute to the biofilm formation of E. coli.
ISSN:	1342-4815 1884-0205
DOI:	10.4265/bio.16.69