The Mechanism of the Titanium-Catalyzed Hydroaminoalkylation of Alkenes

The Mechanism of the Titanium-Catalyzed Hydroaminoalkylation of Alkenes

Kinetic studies on the intramolecular titanium‐catalyzed hydroaminoalkylation of alkenes (see scheme) are consistent with theoretical results and lead to the conclusion that the rate‐determining step of the catalytic cycle is the CH activation at the α position to the nitrogen atom. The reaction ha...

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Veröffentlicht in:Angewandte Chemie International Edition 2011-07, Vol.50 (28), p.6401-6405
Hauptverfasser: Prochnow, Insa, Zark, Patrick, Müller, Thomas, Doye, Sven
Format: Artikel
Sprache:eng
Schlagworte:
alkenes
amines
CH activation
homogeneous catalysis
titanium
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Zusammenfassung:Kinetic studies on the intramolecular titanium‐catalyzed hydroaminoalkylation of alkenes (see scheme) are consistent with theoretical results and lead to the conclusion that the rate‐determining step of the catalytic cycle is the CH activation at the α position to the nitrogen atom. The reaction has a high activation energy and involves a moderately ordered transition state.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201101239