Computed Tomography Detects Tissue Formation in a Stented Engineered Heart Valve

Tissue-engineered heart valves (TEHV) are being explored as an alternative to conventional heart valve prostheses. Using the classic tissue engineering paradigm, a stented tri-leaflet valve is fabricated. Subsequently, the construct is implanted into the pulmonary position in a sheep. Follow-up by m...

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Veröffentlicht in:	The Annals of thoracic surgery 2011-07, Vol.92 (1), p.344-345
Hauptverfasser:	de Heer, Linda M., MD, Budde, Ricardo P.J., MD, PhD, Vonken, Evert-Jan P.A., MD, PhD, Baaijens, Frank P.T., PhD, Gründeman, Paul F., MD, PhD, van Herwerden, Lex A., MD, PhD, Hoerstrup, Simon P., MD, PhD, Kluin, Jolanda, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Cardiology. Vascular system Cardiothoracic Surgery Diagnostic Imaging - methods Disease Models, Animal Echocardiography, Doppler - methods Follow-Up Studies Graft Survival Heart Valve Prosthesis Heart Valve Prosthesis Implantation - methods Magnetic Resonance Imaging - methods Medical sciences Pneumology Pulmonary Valve - diagnostic imaging Pulmonary Valve - surgery Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Risk Assessment Sheep Stents Surgery Time Factors Tissue Engineering - methods Tomography, X-Ray Computed - methods
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Zusammenfassung:	Tissue-engineered heart valves (TEHV) are being explored as an alternative to conventional heart valve prostheses. Using the classic tissue engineering paradigm, a stented tri-leaflet valve is fabricated. Subsequently, the construct is implanted into the pulmonary position in a sheep. Follow-up by means of computed tomography, magnetic resonance imaging, and echocardiography was used to assess tissue formation. After 4 weeks, the scaffold of the TEHV has degraded and new tissue is formed. However, small areas without tissue formation were present at macroscopic inspection. This phenomenon was only visible on computed tomographic images. Therefore, computed tomography appears a promising technique for in vivo follow-up of tissue formation in tissue-engineered heart valves.
ISSN:	0003-4975 1552-6259
DOI:	10.1016/j.athoracsur.2010.12.063