Flurbiprofen Encapsulation Using Pluronic Triblock Copolymers

Pulsed-field gradient stimulated-echo nuclear magnetic resonance (NMR) and surface tension measurements have been used to study the effect of drug addition on the micellization behavior of pluronic triblock copolymers (P103, P123, and L43). The addition of 0.6 wt % flurbiprofen to Pluronic P123 and...

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Veröffentlicht in:	Langmuir 2011-07, Vol.27 (13), p.8054-8060
Hauptverfasser:	Alexander, Shirin, Cosgrove, Terence, Prescott, Stuart W, Castle, Thomas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Colloidal state and disperse state Colloids: Surfactants and Self-Assembly, Dispersions, Emulsions, Foams Drug Stability Emulsions - chemistry Exact sciences and technology Flurbiprofen - chemistry General and physical chemistry Magnetic Resonance Spectroscopy Micelles Micelles. Thin films Models, Molecular Molecular Structure Poloxalene - chemistry Solubility Surface physical chemistry Surface Tension
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Zusammenfassung:	Pulsed-field gradient stimulated-echo nuclear magnetic resonance (NMR) and surface tension measurements have been used to study the effect of drug addition on the micellization behavior of pluronic triblock copolymers (P103, P123, and L43). The addition of 0.6 wt % flurbiprofen to Pluronic P123 and P103 solutions reduced their cmc and promoted micellization. Also, a substantial increase in the hydrodynamic radius of Pluronic P103 from 5 to 10 nm was observed, along with an increased fraction of polymer micellized, demonstrating that the polymers solubilize this nonsteroidal anti-inflammatory drug.
ISSN:	0743-7463 1520-5827
DOI:	10.1021/la201124c