Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II

A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercal...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-05, Vol.21 (10), p.3117-3121
Hauptverfasser:	Shanab, Karem, Schirmer, Eva, Wulz, Eva, Weissenbacher, Barbara, Lassnig, Sigrid, Slanz, Rita, Fösleitner, Germana, Holzer, Wolfgang, Spreitzer, Helmut, Schmidt, Peter, Aicher, Babette, Müller, Gilbert, Günther, Eckhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer compounds Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects cytotoxicity DNA Drug Screening Assays, Antitumor General aspects Humans Medical sciences Molecular Structure Naphthoquinones - chemistry Pharmacology. Drug treatments Pyrroles - chemical synthesis Pyrroles - chemistry Pyrroles - pharmacology Structure-Activity Relationship synthesis
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Zusammenfassung:	A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2011.03.013