A rat experimental model for the design of vaccines against tumor associated antigens Tn and Sialyl-Tn

Clones either strongly or barely expressing the Tn and Sialyl-Tn antigens were isolated from a rat colon carcinoma cell line. Expression of the antigens in normal rat tissues was very restricted and vaccination using Ovine Submaxillary Mucin as the immunogen could delay growth of the Sialyl-Tn posit...

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Veröffentlicht in:	Glycoconjugate journal 1999-11, Vol.16 (11), p.681-684
Hauptverfasser:	Hallouin, F, Goupille, C, Rocher, J, Le Pendu, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Tumor-Associated, Carbohydrate - biosynthesis Antigens, Tumor-Associated, Carbohydrate - immunology Cells Cloning, Organism Enzyme-Linked Immunosorbent Assay Female Immunization Mice Models, Biological Mucins - immunology Neoplasm Transplantation Rats Rats, Inbred Strains Rodents Submandibular Gland - metabolism Tissue Distribution Tumor Cells, Cultured Vaccination
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Beschreibung
Zusammenfassung:	Clones either strongly or barely expressing the Tn and Sialyl-Tn antigens were isolated from a rat colon carcinoma cell line. Expression of the antigens in normal rat tissues was very restricted and vaccination using Ovine Submaxillary Mucin as the immunogen could delay growth of the Sialyl-Tn positive cells, but not of the Sialyl-Tn negative cells in syngeneic rats. The model should be useful for testing new anti-Tn or Sialyl-Tn vaccination protocols.
ISSN:	0282-0080 1573-4986
DOI:	10.1023/A:1007199124074