HIV-1 decreases the levels of neurotrophins in human lymphocytes

Neurotrophins control cell survival. Therefore, we examined whether HIV-1 reduces neurotrophin levels. Serum of HIV-positive individuals exhibited lower concentrations of brain-derived neurotrophic factor (BDNF), but not of other neurotrophins, than HIV-negative individuals. In addition, R5 and X4 s...

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Veröffentlicht in:	AIDS (London) 2011-05, Vol.25 (8), p.1126-1128
Hauptverfasser:	AVDOSHINA, Valeriya, GARZINO-DEMO, Alfredo, BACHIS, Alessia, MONACO, Maria C. G, MAKI, Pauline M, TRACTENBERG, Rochelle E, CHENGLONG LIU, YOUNG, Mary A, MOCCHETTI, Italo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Brain-Derived Neurotrophic Factor - metabolism HIV Infections - metabolism HIV-1 - immunology Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Lymphocyte Count Medical sciences Nerve Growth Factors - metabolism RNA, Messenger Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	Neurotrophins control cell survival. Therefore, we examined whether HIV-1 reduces neurotrophin levels. Serum of HIV-positive individuals exhibited lower concentrations of brain-derived neurotrophic factor (BDNF), but not of other neurotrophins, than HIV-negative individuals. In addition, R5 and X4 strains of HIV-1 decreased BDNF expression in T cells. Our results support the hypothesis that reduced levels of BDNF may be a risk factor for T-cell apoptosis and for neurological complications associated with HIV-1 infection.
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0b013e32834671b3