The inv(3)(q21q26)/t(3;3)(q21;q26) is frequently accompanied by alterations of the RUNX1, KRAS and NRAS and NF1 genes and mediates adverse prognosis both in MDS and in AML: a study in 39 cases of MDS or AML

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Veröffentlicht in:	Leukemia 2011-05, Vol.25 (5), p.874-877
Hauptverfasser:	Haferlach, C, Bacher, U, Haferlach, T, Dicker, F, Alpermann, T, Kern, W, Schnittger, S
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/68 692/699/67/1990/1673 692/699/67/1990/283/1897 692/700/1750 Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Cancer Research Chromosome abnormalities Chromosome Inversion Chromosomes, Human, Pair 3 - genetics Core Binding Factor Alpha 2 Subunit - genetics Critical Care Medicine Female Gene mutations Genes, ras - genetics Genetic aspects Hematologic and hematopoietic diseases Hematology Humans Indexing in process Intensive Internal Medicine letter-to-the-editor Leukemia, Myeloid, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Medicine Medicine & Public Health Middle Aged Myelodysplastic Syndromes - genetics Neurofibromin 1 - genetics Oncology Polymerase chain reaction Prognosis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Runx1 protein Survival Rate Translocation, Genetic - genetics Young Adult
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