Multiple Graph Alignment for the Structural Analysis of Protein Active Sites

Multiple Graph Alignment for the Structural Analysis of Protein Active Sites

Using inexact graph-matching techniques, one is able to identify both conserved areas and regions of difference among different binding pockets. [...] using multiple graph alignments, it is possible to characterize functional protein families and to examine differences among related protein families...

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Veröffentlicht in:IEEE/ACM transactions on computational biology and bioinformatics 2007-04, Vol.4 (2), p.310-320
Hauptverfasser: Weskamp, Nils, Hullermeier, Eyke, Kuhn, Daniel, Klebe, Gerhard
Format: Artikel
Sprache:eng
Schlagworte:
Enzymes
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Beschreibung
Zusammenfassung:Using inexact graph-matching techniques, one is able to identify both conserved areas and regions of difference among different binding pockets. [...] using multiple graph alignments, it is possible to characterize functional protein families and to examine differences among related protein families independent of sequence or fold homology.
ISSN:1545-5963
1557-9964
DOI:10.1109/TCBB.2007.358301