Synthesis and screening of (E)-1-(β-d-galactopyranosyl)-4-(aryl)but-3-ene-2-one against Mycobacterium tuberculosis

A series of galactose-derived aryl enones were synthesised and screened against Mycobacterium tuberculosis H₃₇Rv. Preliminary results were promising with MIC values in the range 1.56–12.5μg/mL.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-07, Vol.21 (13), p.3947-3950
Hauptverfasser:	Mugunthan, G, Ramakrishna, Kuppala, Sriram, Dharmarajan, Yogeeswari, Perumal, Ravindranathan Kartha, K.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - chemical synthesis Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Biological and medical sciences chemistry Galactose - chemical synthesis Galactose - chemistry Galactose - pharmacology Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Minimum inhibitory concentration Molecular Structure Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Pharmacology. Drug treatments Pyrans - chemical synthesis Pyrans - chemistry Pyrans - pharmacology screening Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A series of galactose-derived aryl enones were synthesised and screened against Mycobacterium tuberculosis H₃₇Rv. Preliminary results were promising with MIC values in the range 1.56–12.5μg/mL.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2011.05.037