Anticonvulsant Activity and Toxicity Evaluation of Cu super(II) and Zn super(II) Metal Complexes Derived from Triazole-Quinoline Ligands

Anticonvulsant Activity and Toxicity Evaluation of Cu super(II) and Zn super(II) Metal Complexes Derived from Triazole-Quinoline Ligands

A novel Cu super(II) and Zn super(II) complexes of triazolo-quinoline derivatives were synthesized by in situ method and were characterized by the spectro-analytical methods and their pharmacological properties were evaluated. The compound C3 has exhibited promising anticonvulsant activity towards t...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 2010-12, Vol.58 (12), p.1569-1575
Hauptverfasser: Kulkarni, N V, Budagumpi, S, Kurdekar, G S, Revankar, V K, Didagi, S
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel Cu super(II) and Zn super(II) complexes of triazolo-quinoline derivatives were synthesized by in situ method and were characterized by the spectro-analytical methods and their pharmacological properties were evaluated. The compound C3 has exhibited promising anticonvulsant activity towards the electroshock induced seizures in Wis-tar rats and possesses low toxicity, providing a high safety profile.
ISSN:0009-2363