Efficient aerobic oxidative synthesis of 2-aryl quinazolines via benzyl C-H bond amination catalyzed by 4-hydroxy-TEMPO

Efficient aerobic oxidative synthesis of 2-aryl quinazolines via benzyl C-H bond amination catalyzed by 4-hydroxy-TEMPO

A novel and efficient aerobic protocol for the oxidative synthesis of 2-aryl quinazolines via benzyl C-H bond amination by a one-pot reaction of arylmethanamines with 2-aminobenzoketones and 2-aminobenzaldehydes has been carried out using the 4-hydroxy-TEMPO radical as the catalyst, without any meta...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (27), p.7818-7820
Hauptverfasser: Han, Bing, Wang, Chao, Han, Run-Feng, Yu, Wei, Duan, Xiao-Yong, Fang, Ran, Yang, Xiu-Long
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel and efficient aerobic protocol for the oxidative synthesis of 2-aryl quinazolines via benzyl C-H bond amination by a one-pot reaction of arylmethanamines with 2-aminobenzoketones and 2-aminobenzaldehydes has been carried out using the 4-hydroxy-TEMPO radical as the catalyst, without any metals or additives.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc12308d