Non-Cp titanium alkoxide-based homolytic ring-opening of epoxides by an intramolecular hydrogen abstraction in β-titanoxy radical intermediates

Non-Cp titanium alkoxide-based homolytic ring-opening of epoxides by an intramolecular hydrogen abstraction in β-titanoxy radical intermediates

A low-valent titanium species derived in situ from Ti(O-i-Pr)(4), Me(3)SiCl and Mg powder in tetrahydrofuran reacted with epoxides to selectively provide less hindered alcohols via a homolytic ring-opening of epoxides, in which the intermediate β-titanoxy radical intramolecularly abstracted a hydrog...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (27), p.7857-7859
Hauptverfasser: Kawaji, Tsuyoshi, Shohji, Noriaki, Miyashita, Kenji, Okamoto, Sentaro
Format: Artikel
Sprache:eng
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Zusammenfassung:A low-valent titanium species derived in situ from Ti(O-i-Pr)(4), Me(3)SiCl and Mg powder in tetrahydrofuran reacted with epoxides to selectively provide less hindered alcohols via a homolytic ring-opening of epoxides, in which the intermediate β-titanoxy radical intramolecularly abstracted a hydrogen atom from an alkoxy moiety in the titanium complexes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc12969d