A regio- and stereoselective synthesis of trisubstituted alkenes via gold(I)-catalyzed hydrophosphoryloxylation of haloalkynes

A regio- and stereoselective synthesis of trisubstituted alkenes via gold(I)-catalyzed hydrophosphoryloxylation of haloalkynes

A new stereoselective synthesis of trisubstituted alkenes is developed. Hydrophosphoryloxylation of haloalkynes provides Z-alkenyl halophosphates, which undergo Pd-catalyzed consecutive cross-coupling reactions to afford regio- and stereodefined trisubstituted alkenes.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (27), p.7851-7853
Hauptverfasser: Chary, Bathoju Chandra, Kim, Sunggak, Shin, Doosup, Lee, Phil Ho
Format: Artikel
Sprache:eng
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Zusammenfassung:A new stereoselective synthesis of trisubstituted alkenes is developed. Hydrophosphoryloxylation of haloalkynes provides Z-alkenyl halophosphates, which undergo Pd-catalyzed consecutive cross-coupling reactions to afford regio- and stereodefined trisubstituted alkenes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc12052b