Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells

Rutin is a flavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutin in HTC cells. In the MTT assay, the...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2011-07, Vol.63 (5), p.459-465
Hauptverfasser:	Cristina Marcarini, Juliana, Ferreira Tsuboy, Marcela Stefanini, Cabral Luiz, Rodrigo, Regina Ribeiro, Lucia, Beatriz Hoffmann-Campo, Clara, Ségio Mantovani, Mário
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity Antimutagenic Agents - pharmacology antioxidants Apoptosis Apoptosis - drug effects benzo(a)pyrene Benzo(a)pyrene - toxicity Biological and medical sciences Cell Line, Tumor cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects cell viability Comet Assay Cytotoxicity diet DNA Damage Dose-Response Relationship, Drug Flavonoid rutin genotoxicity HTC human health Investigative techniques, diagnostic techniques (general aspects) Liver Neoplasms, Experimental - pathology Medical sciences Micronuclei, Chromosome-Defective - chemically induced Micronucleus Tests Mutagens - toxicity Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques protective effect Protector effect Rats rutin Rutin - pharmacology Rutin - toxicity
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