A mouse knockout library for secreted and transmembrane proteins

Tang et al . present the first large-scale, gene-specific library of knockout mice. They disrupt 472 genes encoding secreted or transmembrane proteins and report the results of a comprehensive phenotypic analysis. Large collections of knockout organisms facilitate the elucidation of gene functions....

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Veröffentlicht in:Nature biotechnology 2010-07, Vol.28 (7), p.749-755
Hauptverfasser: Tang, Tracy, Li, Li, Tang, Jerry, Li, Yun, Lin, Wei Yu, Martin, Flavius, Grant, Deanna, Solloway, Mark, Parker, Leon, Ye, Weilan, Forrest, William, Ghilardi, Nico, Oravecz, Tamas, Platt, Kenneth A, Rice, Dennis S, Hansen, Gwenn M, Abuin, Alejandro, Eberhart, Derek E, Godowski, Paul, Holt, Kathleen H, Peterson, Andrew, Zambrowicz, Brian P, de Sauvage, Frederic J
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Sprache:eng
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