CD4 +CD28 null T lymphocytes are expanded in young women with polycystic ovary syndrome

Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4 +CD28 null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and...

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Veröffentlicht in:	Fertility and sterility 2011-06, Vol.95 (8), p.2651-2654
Hauptverfasser:	Niccoli, Giampaolo, Apa, Rosanna, Lanzone, Antonio, Liuzzo, Giovanna, Spaziani, Cristina, Sagnella, Francesca, Cosentino, Nicola, Moro, Francesca, Martinez, Daniela, Morciano, Andrea, Bacà, Marco, Pazzano, Vincenzo, Gangale, Maria Francesca, Tropea, Anna, Crea, Filippo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Analysis of Variance Biomarkers - blood C-Reactive Protein - analysis Cardiovascular Diseases - immunology Case-Control Studies CD28 Antigens - metabolism CD4-Positive T-Lymphocytes - immunology Cell Proliferation Female Humans Hyperinsulinemia Hyperinsulinism - immunology inflammation Inflammation Mediators - blood Italy Linear Models polycystic ovary syndrome Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - immunology Risk Assessment Risk Factors T lymphocytes Young Adult
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Zusammenfassung:	Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4 +CD28 null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2011.01.129