Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study

Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant p...

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Veröffentlicht in:	Fertility and sterility 2011-06, Vol.95 (8), p.2574-2577
Hauptverfasser:	Kalfa, Nicolas, M.D., Ph.D, Paris, Françoise, M.D, Soyer-Gobillard, Marie-Odile, Ph.D, Daures, Jean-Pierre, M.D., Ph.D, Sultan, Charles, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	abnormal development Biological and medical sciences boys Cohort Effect Cohort Studies daughters DES diethylstilbestrol Diethylstilbestrol - adverse effects Endocrine Disruptors - adverse effects environment epigenetic estrogens Estrogens, Non-Steroidal - adverse effects Female France Gynecology. Andrology. Obstetrics Humans Hypospadias Hypospadias - chemically induced Hypospadias - epidemiology Hypospadias - genetics Internal Medicine Male Male genital diseases males Malformations of the urinary system Maternal Exposure Medical sciences mice Nephrology. Urinary tract diseases Non tumoral diseases Obstetrics and Gynecology Pedigree Pregnancy Prenatal Exposure Delayed Effects Prevalence Risk Assessment Risk Factors Sex Factors Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland women
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