Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study

Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study

Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant p...

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Veröffentlicht in:Fertility and sterility 2011-06, Vol.95 (8), p.2574-2577
Hauptverfasser: Kalfa, Nicolas, M.D., Ph.D, Paris, Françoise, M.D, Soyer-Gobillard, Marie-Odile, Ph.D, Daures, Jean-Pierre, M.D., Ph.D, Sultan, Charles, M.D., Ph.D
Format: Artikel
Sprache:eng
Schlagworte:
abnormal development
Biological and medical sciences
boys
Cohort Effect
Cohort Studies
daughters
DES
diethylstilbestrol
Diethylstilbestrol - adverse effects
Endocrine Disruptors - adverse effects
environment
epigenetic
estrogens
Estrogens, Non-Steroidal - adverse effects
Female
France
Gynecology. Andrology. Obstetrics
Humans
Hypospadias
Hypospadias - chemically induced
Hypospadias - epidemiology
Hypospadias - genetics
Internal Medicine
Male
Male genital diseases
males
Malformations of the urinary system
Maternal Exposure
Medical sciences
mice
Nephrology. Urinary tract diseases
Non tumoral diseases
Obstetrics and Gynecology
Pedigree
Pregnancy
Prenatal Exposure Delayed Effects
Prevalence
Risk Assessment
Risk Factors
Sex Factors
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
women
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Beschreibung
Zusammenfassung:Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2011.02.047