Don't be a clot: A radiologist's guide to haemostasis including novel antiplatelet and anticoagulant therapies

Normal haemostasis relies on the complex interactions of the coagulation cascade, platelets, and the endothelium. In this review, the roles of each of these elements are described as well as common causes for their derangement. Haemostasis may be manipulated via pharmacological means and in recent y...

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Veröffentlicht in:	Clinical radiology 2011-08, Vol.66 (8), p.693-700
Hauptverfasser:	Godfrey, E.M, Godfrey, A.L, Perry, D.J, Shaw, A.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - pharmacology Biological and medical sciences Blood Coagulation - drug effects Blood Coagulation - physiology Blood Coagulation - radiation effects Blood Coagulation Disorders - etiology Blood Platelets - physiology Blood. Blood coagulation. Reticuloendothelial system Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Endothelium, Vascular - radiation effects Fundamental and applied biological sciences. Psychology Hemostasis - drug effects Hemostasis - physiology Hemostasis - radiation effects Humans Medical sciences Pharmacology. Drug treatments Platelet Aggregation Inhibitors - therapeutic use Practice Guidelines as Topic Prothrombin Time Radiology Radiology, Interventional - methods Radiology, Interventional - standards Thrombocytopenia - etiology Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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Zusammenfassung:	Normal haemostasis relies on the complex interactions of the coagulation cascade, platelets, and the endothelium. In this review, the roles of each of these elements are described as well as common causes for their derangement. Haemostasis may be manipulated via pharmacological means and in recent years there has been a significant increase in the number of agents available for influencing haemostatic mechanisms. It is essential that radiologists are aware of these mechanisms and drugs if they are to perform image-guided procedures safely. In addition to describing the relevant pathways and drugs, practical tips are provided.
ISSN:	0009-9260 1365-229X
DOI:	10.1016/j.crad.2011.03.014