Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice

Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ liga...

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Veröffentlicht in:	Fertility and sterility 2011-06, Vol.95 (8), p.2534-2537.e1
Hauptverfasser:	Elia, Evelin M, Pustovrh, Carolina, Ph.D, Amalfi, Sabrina, Devoto, Luigi, Ph.D, Motta, Alicia Beatriz, Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects Animals Arachidonate 12-Lipoxygenase - metabolism Arachidonate 15-Lipoxygenase - metabolism Biological and medical sciences Dehydroepiandrosterone Disease Models, Animal Down-Regulation Female Female genital diseases genes glycemic effect Gynecology. Andrology. Obstetrics hyperandrogenism Hyperandrogenism - chemically induced Hyperandrogenism - genetics Hyperandrogenism - metabolism Hyperandrogenism - physiopathology Hypoglycemic Agents - pharmacology Internal Medicine Ligands Lipoxygenases Medical sciences metformin Metformin - pharmacology Mice Mice, Inbred BALB C Non tumoral diseases Obstetrics and Gynecology peroxisome proliferator activated receptor gamma polycystic ovary syndrome PPAR gamma - agonists PPAR gamma - genetics PPAR gamma - metabolism protein synthesis RNA, Messenger - metabolism Sexual Development uterine tissue uterus Uterus - drug effects Uterus - metabolism Uterus - physiopathology
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Zusammenfassung:	Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2011.02.004