Effect of cyclosporine pretreatment on mitochondrial function in vitrified bovine mature oocytes

Vitrification had a significantly negative impact on the mitochondrial function of bovine oocytes. However, 40 μg/mL cyclosporine pretreatment before vitrification contributed greatly to maintaining mitochondrial membrane potential and adenosine triphosphate content, decreasing reactive oxygen speci...

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Veröffentlicht in:	Fertility and sterility 2011-06, Vol.95 (8), p.2786-2788
Hauptverfasser:	Zhao, Xue-Ming, Ph.D, Du, Wei-Hua, Ph.D, Wang, Dong, Ph.D, Hao, Hai-Sheng, M.Sc, Liu, Yan, Ph.D, Qin, Tong, Ph.D, Zhu, Hua-Bin, M.Sc
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Adenosine Triphosphate - metabolism Animals Biological and medical sciences Blastocyst - drug effects bovine Calcimycin - pharmacology Cattle Cryopreservation CsA pretreatment Cyclosporine - pharmacology Embryo Culture Techniques Female Gynecology. Andrology. Obstetrics Internal Medicine Ionophores - pharmacology Medical sciences Membrane Potential, Mitochondrial - drug effects mitochondria Mitochondria - drug effects Mitochondria - metabolism Obstetrics and Gynecology oocytes Oocytes - drug effects Oocytes - metabolism Parthenogenesis - drug effects Reactive Oxygen Species - metabolism Time Factors Vitrification
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Beschreibung
Zusammenfassung:	Vitrification had a significantly negative impact on the mitochondrial function of bovine oocytes. However, 40 μg/mL cyclosporine pretreatment before vitrification contributed greatly to maintaining mitochondrial membrane potential and adenosine triphosphate content, decreasing reactive oxygen species level, and thereby increasing the developmental ability of vitrified oocytes.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2011.04.089