Involvement of anticentromere antibody in interference with oocyte meiosis and embryo cleavage

The aim of this study was to investigate the clinical significance of anticentromere antibody (ACA) among types of antinuclear antibody (ANA) in the properties of oocytes retrieved from infertile women. The rate of metaphase II oocytes or embryo cleavage was significantly decreased in patients with...

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Veröffentlicht in:	Fertility and sterility 2011-06, Vol.95 (8), p.2729-2731
Hauptverfasser:	Shirota, Kyoko, M.D., Ph.D, Nagata, Yumi, M.D., Ph.D, Honjou, Kou, M.D, Tsujioka, Hiroshi, M.D., Ph.D, Yoshizato, Toshiyuki, M.D., Ph.D, Miyamoto, Shingo, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Antinuclear - analysis anticentromere antibody Antinuclear antibody Biological and medical sciences Biomarkers - analysis Birth control Chi-Square Distribution Cleavage Stage, Ovum Down-Regulation Female Fluorescent Antibody Technique Gynecology. Andrology. Obstetrics Humans Infertility, Female - immunology Infertility, Female - pathology Infertility, Female - therapy Internal Medicine intracytoplasmic sperm injection Japan Male Medical sciences Meiosis metaphase Obstetrics and Gynecology Oocyte Retrieval oocytes Oocytes - immunology Oocytes - pathology Ovulation Induction patients Sperm Injections, Intracytoplasmic Sterility. Assisted procreation women
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Zusammenfassung:	The aim of this study was to investigate the clinical significance of anticentromere antibody (ACA) among types of antinuclear antibody (ANA) in the properties of oocytes retrieved from infertile women. The rate of metaphase II oocytes or embryo cleavage was significantly decreased in patients with positive ACA compared with patients with negative ACA, suggesting that ACA is an essential marker for flawed oocytes in infertile women with any type of ANA.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2011.01.013