Association of sperm morphology and the sperm deformity index (SDI) with poly (ADP-ribose) polymerase (PARP) cleavage inhibition

Apoptosis was induced in immature and mature sperm in the presence or absence of poly (ADP-ribose) polymerase (PARP) inhibitor. The association of cleaved (cPARP) with sperm morphology was examined using sperm deformity index (SDI) score. The SDI scores are associated with PARP cleavage as an early...

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Veröffentlicht in:	Fertility and sterility 2011-06, Vol.95 (8), p.2481-2484
Hauptverfasser:	Aziz, Nabil, M.D, Sharma, Rakesh K., Ph.D, Mahfouz, Reda, M.D, Jha, Rajesh, Ph.D, Agarwal, Ashok, Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis Apoptosis - drug effects Benzamides - pharmacology Biological and medical sciences biomarkers Caspase 3 - metabolism Cell Shape - drug effects DNA Fragmentation enzyme inhibition enzyme inhibitors Enzyme Inhibitors - pharmacology flow cytometry Gynecology. Andrology. Obstetrics Humans Hydrogen Peroxide - pharmacology In Situ Nick-End Labeling Internal Medicine Male male fertility Medical sciences NAD ADP-ribosyltransferase Obstetrics and Gynecology Oxidants - pharmacology Oxidative Stress - drug effects PARP cleavage Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein Kinase Inhibitors - pharmacology SDI semen analysis Sperm Head - enzymology Sperm Head - pathology Sperm morphology spermatocytes spermatozoa Spermatozoa - drug effects Spermatozoa - enzymology Spermatozoa - pathology Staurosporine - pharmacology
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Zusammenfassung:	Apoptosis was induced in immature and mature sperm in the presence or absence of poly (ADP-ribose) polymerase (PARP) inhibitor. The association of cleaved (cPARP) with sperm morphology was examined using sperm deformity index (SDI) score. The SDI scores are associated with PARP cleavage as an early marker of apoptosis.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2011.03.095