Effect of Diode Laser on Proliferation and Differentiation of PC12 Cells

This study investigated the effects of diode (GaAlAs) laser irradiation at an effective energy density of 5 or 20 J/cm2 on cell growth factor-induced differentiation and proliferation in pheochromocytoma cells (PC12 cells), and whether those effects were related to activation of the p38 pathway. Las...

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Veröffentlicht in:	Bulletin of Tokyo Dental College 2011, Vol.52(2), pp.95-102
Hauptverfasser:	Saito, Kensuke, Hashimoto, Sadamitsu, Jung, Han-Sung, Shimono, Masaki, Nakagawa, Kan-Ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - radiation effects Cell Proliferation - radiation effects Dentistry GaAlAs laser Lasers, Semiconductor Low-Level Light Therapy MAP Kinase Signaling System - physiology Nerve Growth Factor - pharmacology Nerve Regeneration - radiation effects Neurite differentiation Neurites - drug effects Neurites - metabolism Neurites - radiation effects Neurofilament Proteins - biosynthesis p38 Mitogen-Activated Protein Kinases - metabolism p38 pathway PC12 cells PC12 Cells - radiation effects Proliferation Rats Tubulin - biosynthesis Up-Regulation
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Zusammenfassung:	This study investigated the effects of diode (GaAlAs) laser irradiation at an effective energy density of 5 or 20 J/cm2 on cell growth factor-induced differentiation and proliferation in pheochromocytoma cells (PC12 cells), and whether those effects were related to activation of the p38 pathway. Laser irradiation at 20 J/cm2 significantly decreased the number of PC12 cells, while no difference was seen between the 5 J/cm2 group and the control group (p
ISSN:	0040-8891
DOI:	10.2209/tdcpublication.52.95