Bioactive Neolignans and Lignans from the Bark of Machilus robusta

Sixteen new neolignans and lignans (1–16), together with 12 known analogues, have been isolated from an ethanol extract of the bark of Machilus robusta. Compounds 1 and 2 showed activity against HIV-1 replication in vitro, with IC50 values of 2.52 and 2.01 μM, respectively. At 10 μM, 6, 8, and 9 red...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2011-06, Vol.74 (6), p.1444-1452
Hauptverfasser:	Li, Yanru, Cheng, Wei, Zhu, Chenggen, Yao, Chunsuo, Xiong, Liang, Tian, Ye, Wang, Sujuan, Lin, Sheng, Hu, Jinfeng, Yang, Yongchun, Guo, Ying, Yang, Ying, Li, Yan, Yuan, Yuhe, Chen, Naihong, Shi, Jiangong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Galactosamine - pharmacology General pharmacology Hepatocytes - drug effects HIV-1 - drug effects Lauraceae - chemistry Lignans - blood Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular PC12 Cells - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark - chemistry Rats
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Zusammenfassung:	Sixteen new neolignans and lignans (1–16), together with 12 known analogues, have been isolated from an ethanol extract of the bark of Machilus robusta. Compounds 1 and 2 showed activity against HIV-1 replication in vitro, with IC50 values of 2.52 and 2.01 μM, respectively. At 10 μM, 6, 8, and 9 reduced dl-galactosamine-induced hepatocyte (WB-F344 cells) damage, and 9 could additionally attenuate rotenone-induced PC12 cell damage. The known compounds (−)-pinoresinol (17) and (+)-lyoniresinol (18) were active against serum deprivation induced PC12 cell damage.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np2001896